Department of Oncology, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Presidio San Salvatore, Via Lombroso 1, 61122, Pesaro, Italy. catalano_v@yahoo.it. Medical Oncology Unit 1, Department of Clinical and Experimental Oncology, Istituto Oncologico Veneto, IRCCS, Padua, Italy. Unit of Medical Oncology, Department of Translational Research and New Technologies in Medicine, Azienda Ospedaliero-Universitaria Pisana, University of Pisa, Pisa, Italy. Department of Medical Oncology, Campus Bio-Medico, Università di Roma, Rome, Italy. Department of Oncology, Ospedale Universitario, Parma, Italy. Department of Oncology, Azienda Ospedaliera "Ospedali Riuniti Marche Nord", Presidio San Salvatore, Via Lombroso 1, 61122, Pesaro, Italy. Unità di Statistica Medica e Biometria, Department of Biomolecular Sciences, Università "Carlo Bo", Urbino, Italy.